Apigenin 98% CAS 520-36-5 Fabricado En China Food Additive

What Is Apigenin?

1) Apigenin is a plant-derived flavonoid that has significant promise as a skin cancer chemopreventive agent. Apigenin inhibits the expression of involucrin (hINV), a marker of keratinocyte differentiation, is increased by differentiating agents via a protein kinase Cdelta (PKCdelta), Ras, MEKK1, MEK3 cascade that increases AP1 factor level and AP1 factor binding to DNA elements in the hINV promoter. Apigenin suppresses the 12-O-tetradeconylphorbol-13-acetate-dependent increase in AP1 factor expression and binding to the hINV promoter and the increase in hINV promoter activity. Apigenin also inhibits the increase in promoter activity observed following overexpression of PKCdelta, constitutively active Ras, or MEKK1. The suppression of PKCdelta activity is associated with reduced phosphorylation of PKCdelta-Y311. Activation of hINV promoter activity by the green tea polyphenol, (-)-epigellocathecin-3-gallate, is also inhibited by apigenin, suggesting that the two chemopreventive agents can produce opposing actions in keratinocytes. Apigenin, a flavone abundantly found in fruits and vegetables, exhibits antiproliferative, anti-inflammatory, and antimetastatic activities through poorly defined mechanisms. This flavonoid provides selective activity to promote caspase-dependent-apoptosis of leukemia cells and uncover an essential role of PKCdelta during the induction of apoptosis by apigenin. Apigenin markedly induces the expression of death receptor 5 (DR5) and synergistically acts with exogenous soluble recombinant human tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to induce apoptosis in malignant tumor cells. On the other hand, apigenin-mediated induction of DR5 expression is not observed in normal human peripheral blood mononuclear cells. Moreover, apigenin does not sensitize normal human peripheral blood mononuclear cells to TRAIL-induced apoptosis.

2) Apigenin is a natural product found in Camellia sinensis, Apis, and other organisms with data available. 

3) Apigenin is a trihydroxyflavone that is flavone substituted by hydroxy groups at positions 4', 5 and 7. It induces autophagy in leukaemia cells. It has a role as a metabolite and an antineoplastic agent. It is a conjugate acid of an apigenin-7-olate.

Product Applications
 

1. Antioxidant and anti-inflammatory effects: Apigenin is a natural antioxidant that protects cells from free radical damage. In addition, it has anti-inflammatory effects and can reduce the inflammatory response.

2. Antibacterial and antiviral effects: Apigenin has a certain inhibitory effect on some bacteria and viruses, and can be used to develop some drugs to prevent and treat infectious diseases.

3. Lower blood pressure: Apigenin can lower blood pressure in a variety of ways, including dilating blood vessels and slowing heart rate. This makes it a valuable natural blood pressure reducer.

4. Improve heart health: Apigenin can help protect heart health, reduce myocardial ischemia-reperfusion injury, and reduce the incidence of arrhythmia.

5. Protect liver health: Apigenin can inhibit the deposition of fat in liver cells, improve liver function and reduce liver damage.

6. Anti-inflammatory and anti-cancer: Apigenin has a certain anti-inflammatory effect, which can prevent cell mutation and cancer. In addition, it also has anti-cancer effects, which can inhibit the growth and spread of tumors.

7. Anti-anxiety and depression: Apigenin can relieve anxiety and depression symptoms, improve mood levels, and help improve mental health.



PNP Biotech, located in Chengdu, Sichuan Province, China, is an international trading company with over 20 years of experience supplying nutritional ingredients.

PNP stands for Prudent and Persistent, and with this belief and value in mind, we provide high-quality products and proven, reliable supply chain support to our customers worldwide.

With our manufacturing plants throughout China, we can produce stable quality products and offer a wide range of customized services by directly controlling the quality of our production.

In addition, we are constantly researching new technologies, developing new products, and actively setting up warehouses overseas to reduce our customers' purchasing and shipping costs.

We believe that as long as we put in efforts and sincerity, we can reap long-term and friendly cooperation with our customers, and we believe that soon, we will also start a brand new journey of collaboration with you!

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