China Factory High Quality Nutritional Ingredients Raw Materials Apigenin 98% CAS 520-36-5 Fabricado En China Food Additive

Product Details
Customization: Available
CAS No.: 520-36-5
Formula: C15h10o5
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  • China Factory High Quality Nutritional Ingredients Raw Materials Apigenin 98% CAS 520-36-5 Fabricado En China Food Additive
  • China Factory High Quality Nutritional Ingredients Raw Materials Apigenin 98% CAS 520-36-5 Fabricado En China Food Additive
  • China Factory High Quality Nutritional Ingredients Raw Materials Apigenin 98% CAS 520-36-5 Fabricado En China Food Additive
  • China Factory High Quality Nutritional Ingredients Raw Materials Apigenin 98% CAS 520-36-5 Fabricado En China Food Additive
  • China Factory High Quality Nutritional Ingredients Raw Materials Apigenin 98% CAS 520-36-5 Fabricado En China Food Additive
  • China Factory High Quality Nutritional Ingredients Raw Materials Apigenin 98% CAS 520-36-5 Fabricado En China Food Additive
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  • Overview
  • Product Description
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Overview

Basic Info.

Packaging Material
Paper
Storage Method
Normal
Shelf Life
>12 Months
Nutrient Composition
Apigenin
Resource
Celery
The content of active substances
>90%
Sample
50 Grams Maximum Free Sample
MOQ
25kg
Appearance
Powder
Shipping
by Ocean or Airfreight; FedEx
Transport Package
25kg/Drum
Specification
98%
Origin
China
HS Code
2914501900
Production Capacity
20000kg/Month

Product Description

 China Factory High Quality Nutritional Ingredients Raw Materials Apigenin 98% CAS 520-36-5 Fabricado En China Food Additive
 
Product Description
 

What Is Apigenin?

1) Apigenin is a plant-derived flavonoid that has significant promise as a skin cancer chemopreventive agent. Apigenin inhibits the expression of involucrin (hINV), a marker of keratinocyte differentiation, which is increased by differentiating agents via a protein kinase C delta (PKCdelta), Ras, MEKK1, MEK3 cascade that increases AP1 factor level and AP1 factor binding to DNA elements in the hINV promoter. Apigenin suppresses the 12-O-tetradeconylphorbol-13-acetate-dependent increase in AP1 factor expression and binding to the hINV promoter and the increase in hINV promoter activity. Apigenin also inhibits the increase in promoter activity observed following overexpression of PKCdelta, constitutively active Ras, or MEKK1. The suppression of PKCdelta activity is associated with reduced phosphorylation of PKCdelta-Y311. Activation of hINV promoter activity by the green tea polyphenol, (-)-epigallocatechin-3-gallate, is also inhibited by apigenin, suggesting that the two chemopreventive agents can produce opposing actions in keratinocytes. Apigenin, a flavone abundantly found in fruits and vegetables, exhibits antiproliferative, anti-inflammatory, and antimetastatic activities through poorly defined mechanisms. This flavonoid provides selective activity to promote caspase-dependent apoptosis of leukemia cells and uncover an essential role of PKCdelta during the induction of apoptosis by apigenin. Apigenin markedly induces the expression of death receptor 5 (DR5) and synergistically acts with exogenous soluble recombinant human tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to induce apoptosis in malignant tumor cells. On the other hand, apigenin-mediated induction of DR5 expression is not observed in normal human peripheral blood mononuclear cells. Moreover, apigenin does not sensitize normal human peripheral blood mononuclear cells to TRAIL-induced apoptosis.

2) Apigenin is a natural product found in 
Camellia sinensis, Apis, and other organisms with data available. 

3) Apigenin is a 
trihydroxyflavone that is flavone substituted by hydroxy groups at positions 4', 5 and 7. It induces autophagy in leukemia cells. It has a role as a metabolite and an antineoplastic agent. It is a conjugate acid of an apigenin-7-olate.

 

China Factory High Quality Nutritional Ingredients Raw Materials Apigenin 98% CAS 520-36-5 Fabricado En China Food Additive

 

Product Applications
 

1. Antioxidant and anti-inflammatory effects: Apigenin is a natural antioxidant that protects cells from free radical damage. In addition, it has anti-inflammatory effects and can reduce the inflammatory response.

2. Antibacterial and antiviral effects: Apigenin has a certain inhibitory effect on some bacteria and viruses, and can be used to develop some drugs to prevent and treat infectious diseases.

3. Lower blood pressure: Apigenin can lower blood pressure in a variety of ways, including dilating blood vessels and slowing heart rate. This makes it a valuable natural blood pressure reducer.

4. Improve heart health: Apigenin can help protect heart health, reduce myocardial ischemia-reperfusion injury, and reduce the incidence of arrhythmia.

5. Protect liver health: Apigenin can inhibit the deposition of fat in liver cells, improve liver function and reduce liver damage.

6. Anti-inflammatory and anti-cancer: Apigenin has a certain anti-inflammatory effect, which can prevent cell mutation and cancer. In addition, it also has anti-cancer effects, which can inhibit the growth and spread of tumors.

7. Anti-anxiety and depression: Apigenin can relieve anxiety and depression symptoms, improve mood levels, and help improve mental health.



China Factory High Quality Nutritional Ingredients Raw Materials Apigenin 98% CAS 520-36-5 Fabricado En China Food Additive

PNP Biotech, located in Chengdu, Sichuan Province, China, is an international trading company with over 20 years of experience supplying nutritional ingredients.

PNP stands for Prudent and Persistent, and with this belief and value in mind, we provide high-quality products and proven, reliable supply chain support to our customers worldwide.

With our manufacturing plants throughout China, we can produce stable quality products and offer a wide range of customized services by directly controlling the quality of our production.

In addition, we are constantly researching new technologies, developing new products, and actively setting up warehouses overseas to reduce our customers' purchasing and shipping costs.

We believe that as long as we put in efforts and sincerity, we can reap long-term and friendly cooperation with our customers, and we believe that soon, we will also start a brand new journey of collaboration with you!



China Factory High Quality Nutritional Ingredients Raw Materials Apigenin 98% CAS 520-36-5 Fabricado En China Food AdditiveChina Factory High Quality Nutritional Ingredients Raw Materials Apigenin 98% CAS 520-36-5 Fabricado En China Food Additive


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China Factory High Quality Nutritional Ingredients Raw Materials Apigenin 98% CAS 520-36-5 Fabricado En China Food Additive

FAQ
 
You may want to know the following:

Q: What is the price validation?
     Two weeks minimum.

Q: What's your MOQ?
     Our price is based on 25kg MOQ. We also accept smaller quantity orders for your R&D purpose, but the price will be higher due to the additional repack process fee and shipping/handling cost.

Q: Can I get free samples?
     We provide 50 grams maximum free sample if you can take care of the shipping charges.

Q: Is there a discount?
     It is negotiable depending on the quantity and demand details.

Q: What is the shipping method and what is the lead time?
     We ship by ocean or airfreight for most orders and also use express courier for small orders.

Q: What is the shelf life for the products?
     24 months.

Q: Do you accept customized products?
     Yes.

Q: What are the payment terms and method?
     We require 100% prepay for the first order, meanwhile, we will apply for a credit allowance with our insurance company, and we can negotiate the payment terms after that. For payment methods, we accept international wire transfers and L/C.


 

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