| Customization: | Available |
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| CAS No.: | 59-92-7 |
| Formula: | C9h11no4 |
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What Is L-dopa?
L-dopa is a medication used to treat Parkinson's disease by increasing dopamine levels in the brain to alleviate symptoms. It can improve motor function and reduce muscle stiffness and tremors in patients.
L-dopa is an optically active form of dopa having L-configuration. Used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease It has a role as a prodrug, a hapten, a neurotoxin, an antiparkinson drug, a dopaminergic agent, an antidyskinesia agent, an allelochemical, a plant growth retardant, a human metabolite, a mouse metabolite and a plant metabolite. It is a dopa, a L-tyrosine derivative and a non-proteinogenic L-alpha-amino acid. It is a conjugate acid of a L-dopa(1-). It is an enantiomer of a D-dopa. It is a tautomer of a L-dopa zwitterion.
Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prevent metabolism until after it has crossed the blood-brain barrier. Once past the blood-brain barrier, levodopa is metabolized to dopamine and supplements the low endogenous levels of dopamine to treat symptoms of Parkinson's. The first developed drug product that was approved by the FDA was a levodopa and carbidopa combined product called Sinemet that was approved on May 2, 1975.
Product Applications
L-Dopa has the following uses and benefits:
1. Treatment of Parkinson's disease: L-Dopa significantly alleviates motor symptoms, such as tremors, muscle rigidity, and bradykinesia, by increasing dopamine levels in the brain.
2. Improvement of motor function: L-Dopa helps patients regain more normal motor abilities, making daily activities smoother and more independent.
3. Relief of Parkinson 's-related symptoms: L-Dopa can also help reduce some non-motor symptoms of Parkinson's disease, such as depression, anxiety, and sleep disorders, thereby improving the overall quality of life for patients.
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